› 7pmy

Electron Microscopy
3.8Å resolution

HsPepT2 bound to Ala-Phe in the inward facing partially occluded conformation

Released:
DOI: 10.2210/pdb7pmy/pdb
PDB entry 7pmy coloured by chain, front view.
PDB entry 7pmy coloured by chain, side view.
PDB entry 7pmy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Killer M, Wald J, Pieprzyk J, Marlovits TC, Löw C
Sci Adv 7 eabk3259 (2021)
PMID: 34730990
Related structures: EMD-13544

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168627 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Solute carrier family 15 member 2 Chain: A
Molecule details ›
Chain: A
Length: 729 amino acids
Theoretical weight: 81.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16348 (Residues: 1-729; Coverage: 100%)
Gene names: PEPT2, SLC15A2
Sequence domains: POT family
ALA-PHE Chain: B
Molecule details ›
Chain: B
Length: 2 amino acids
Theoretical weight: 236 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-13544
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

6 review citations

Biology of Peptide Transporter 2 in Mammals: New Insights into Its Function, Structure and Regulation.
Wang et al. (2022)
5 more

5 mentions without citation

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
Giacomini et al. (2022)
4 more