› 7po7

X-ray diffraction
2.31Å resolution

Phosphoglycolate phosphatase from Mus musculus

Released:
DOI: 10.2210/pdb7po7/pdb
Model geometry
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PDB entry 7po7 coloured by chain, front view.
PDB entry 7po7 coloured by chain, side view.
PDB entry 7po7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Glycolytic flux control by drugging phosphoglycolate phosphatase.
Jeanclos E, Schlötzer J, Hadamek K, Yuan-Chen N, Alwahsh M, Hollmann R, Fratz S, Yesilyurt-Gerhards D, Frankenbach T, Engelmann D, Keller A, Kaestner A, Schmitz W, Neuenschwander M, Hergenröder R, Sotriffer C, von Kries JP, Schindelin H, Gohla A
OpenAccess logo Nat Commun 13 6845 (2022)
PMID: 36369173

Function and Biology Details

Reactions catalysed: 
sn-glycerol 1-phosphate + H(2)O = glycerol + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycerol-3-phosphate phosphatase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 321 amino acids
Theoretical weight: 34.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8CHP8 (Residues: 1-321; Coverage: 100%)
Gene name: Pgp
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand ACT 8 x ACT
Ligand SO4 8 x SO4
Ligand GOL 15 x GOL
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P1
Unit cell:
a: 84.262Å b: 91.197Å c: 101.317Å
α: 103.457° β: 89.98° γ: 104.632°
R-values:
R R work R free
0.208 0.208 0.23
Expression system: Escherichia coli

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Citations

3 citation in other articles

Glycolytic flux control by drugging phosphoglycolate phosphatase.
Jeanclos et al. (2022)
2 more

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