› 7pp6

Electron Microscopy
3.4Å resolution

MUC2 Tubules of D1D2D3 domains

Released:
DOI: 10.2210/pdb7pp6/pdb
PDB entry 7pp6 coloured by chain, front view.
PDB entry 7pp6 coloured by chain, side view.
PDB entry 7pp6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
Javitt G, Fass D
OpenAccess logo Proc Natl Acad Sci U S A 119 e2116790119 (2022)
PMID: 35377815
Related structures: EMD-13580

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169769 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Mucin-2 Chains: A, B, C, D, E, G
Molecule details ›
Chains: A, B, C, D, E, G
Length: 1245 amino acids
Theoretical weight: 137.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02817 (Residues: 21-1259; Coverage: 24%)
Gene names: MUC2, SMUC
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand CA 12 x CA
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-13580
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion.
Javitt et al. (2022)
2 more