› 7ppg

X-ray diffraction
2.13Å resolution

Function and Biology Details

Reaction catalysed: 
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide phosphoribosyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 492 amino acids
Theoretical weight: 55.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P43490 (Residues: 1-491; Coverage: 100%)
Gene names: NAMPT, PBEF, PBEF1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand PO4 7 x PO4
Ligand 7YX 4 x 7YX
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 82.956Å b: 106.18Å c: 121.34Å
α: 90° β: 96.53° γ: 90°
R-values:
R R work R free
0.255 0.253 0.302
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment.
Xu et al. (2022)
2 other articles