› 7pqt

Electron Microscopy
2.65Å resolution

Apo human Kv3.1 cryo-EM structure

Released:
DOI: 10.2210/pdb7pqt/pdb
PDB entry 7pqt coloured by chain, front view.
PDB entry 7pqt coloured by chain, side view.
PDB entry 7pqt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.
Botte M, Huber S, Bucher D, Klint JK, Rodríguez D, Tagmose L, Chami M, Cheng R, Hennig M, Abdul Rahman W
OpenAccess logo PNAS Nexus 1 pgac083 (2022)
PMID: 36741467
Related structures: EMD-13604

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-gated potassium channel KCNC1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 519 amino acids
Theoretical weight: 58.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48547 (Residues: 1-511; Coverage: 100%)
Gene name: KCNC1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand K 4 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.65Å
Relevant EMDB volumes: EMD-13604
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Targeting ion channels with ultra-large library screening for hit discovery.
Melancon et al. (2023)
1 other article

2 mentions without citation

Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.
Botte et al. (2022)
1 more