› 7psu

X-ray diffraction
1.77Å resolution

Structure of protein kinase CK2alpha mutant K198R associated with the Okur-Chung Neurodevelopmental Syndrome

Released:
DOI: 10.2210/pdb7psu/pdb
PDB entry 7psu coloured by chain, front view.
PDB entry 7psu coloured by chain, side view.
PDB entry 7psu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Enzymological Evidence for an Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2αLys198Arg.
Werner C, Gast A, Lindenblatt D, Nickelsen A, Niefind K, Jose J, Hochscherf J
OpenAccess logo Front Mol Biosci 9 831693 (2022)
PMID: 35445078

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 411 amino acids
Theoretical weight: 47.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-391; Coverage: 100%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand EDO 9 x EDO
Ligand SO4 9 x SO4
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P43212
Unit cell:
a: 127.824Å b: 127.824Å c: 123.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.218
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Predictive functional, statistical and structural analysis of CSNK2A1 and CSNK2B variants linked to neurodevelopmental diseases.
Unni et al. (2022)

1 mention without citation

Genetic Structure in a Small Pelagic Fish Coincides with a Marine Protected Area: Seascape Genetics in Patagonian Fjords.
Canales-Aguirre et al. (2016)