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DNA polymerase from M. tuberculosis

Source organisms:
Biochemical function: DNA polymerase activity
Biological process: DNA biosynthetic process
Cellular component: peptidoglycan-based cell wall

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EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01336
Domain description: OB-fold nucleic acid binding domain
Occurring in:
  1. DNA polymerase III subunit alpha
The deposited structure of PDB entry 7pu7 contains 1 copy of Pfam domain PF01336 (OB-fold nucleic acid binding domain) in DNA polymerase III subunit alpha. Showing 1 copy in chain A.

PF14579
Domain description: Helix-hairpin-helix motif
Occurring in:
  1. DNA polymerase III subunit alpha
The deposited structure of PDB entry 7pu7 contains 1 copy of Pfam domain PF14579 (Helix-hairpin-helix motif) in DNA polymerase III subunit alpha. Showing 1 copy in chain A.

PF17657
Domain description: Bacterial DNA polymerase III alpha subunit finger domain
Occurring in:
  1. DNA polymerase III subunit alpha
The deposited structure of PDB entry 7pu7 contains 1 copy of Pfam domain PF17657 (Bacterial DNA polymerase III alpha subunit finger domain) in DNA polymerase III subunit alpha. Showing 1 copy in chain A.

PF07733
Domain description: Bacterial DNA polymerase III alpha NTPase domain
Occurring in:
  1. DNA polymerase III subunit alpha
The deposited structure of PDB entry 7pu7 contains 1 copy of Pfam domain PF07733 (Bacterial DNA polymerase III alpha NTPase domain) in DNA polymerase III subunit alpha. Showing 1 copy in chain A.

PF02811
Domain description: PHP domain
Occurring in:
  1. DNA polymerase III subunit alpha
The deposited structure of PDB entry 7pu7 contains 1 copy of Pfam domain PF02811 (PHP domain) in DNA polymerase III subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004805
Domain description: Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC
Occurring in:
  1. DNA polymerase III subunit alpha
IPR029460
Domain description: DNA polymerase, helix-hairpin-helix motif
Occurring in:
  1. DNA polymerase III subunit alpha
IPR040982
Domain description: DNA polymerase III alpha subunit finger domain
Occurring in:
  1. DNA polymerase III subunit alpha
IPR041931
Domain description: Bacterial DNA polymerase III alpha subunit, thumb domain
Occurring in:
  1. DNA polymerase III subunit alpha
IPR011708
Domain description: Bacterial DNA polymerase III, alpha subunit, NTPase domain
Occurring in:
  1. DNA polymerase III subunit alpha
IPR004013
Domain description: PHP domain
Occurring in:
  1. DNA polymerase III subunit alpha
IPR003141
Domain description: Polymerase/histidinol phosphatase, N-terminal
Occurring in:
  1. DNA polymerase III subunit alpha
IPR016195
Domain description: Polymerase/histidinol phosphatase-like
Occurring in:
  1. DNA polymerase III subunit alpha

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