› 7pvq

X-ray diffraction
1.55Å resolution

Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in the space group P21221

Released:
DOI: 10.2210/pdb7pvq/pdb
PDB entry 7pvq coloured by chain, front view.
PDB entry 7pvq coloured by chain, side view.
PDB entry 7pvq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Camara-Artigas A, Salinas Garcia MC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 59 amino acids
Theoretical weight: 6.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00519 (Residues: 63-120; Coverage: 5%)
Gene names: ABL, ABL1, JTK7
Sequence domains: SH3 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Unit cell:
a: 27.313Å b: 43.465Å c: 94.854Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.274
Expression system: Escherichia coli BL21(DE3)

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