› 7pvz

X-ray diffraction
2Å resolution

Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant

Released:
DOI: 10.2210/pdb7pvz/pdb
PDB entry 7pvz coloured by chain, front view.
PDB entry 7pvz coloured by chain, side view.
PDB entry 7pvz coloured by chain, top view.
Source organism: Gallus gallus
Entry authors: Camara-Artigas A, Salinas Garcia MC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-523620 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 61 amino acids
Theoretical weight: 6.65 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 81-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P64
Unit cell:
a: 48.788Å b: 48.788Å c: 90.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.231 0.256
Expression system: Escherichia coli BL21(DE3)

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