Function and Biology

Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular component: cytosol

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF10220
Domain description: Smg8_Smg9
Occurring in:
  1. Nonsense-mediated mRNA decay factor SMG8
The deposited structure of PDB entry 7pw5 contains 1 copy of Pfam domain PF10220 (Smg8_Smg9) in Nonsense-mediated mRNA decay factor SMG8. Showing 1 copy in chain B.
The deposited structure of PDB entry 7pw5 contains 1 copy of Pfam domain PF10220 (Smg8_Smg9) in Nonsense-mediated mRNA decay factor SMG9. Showing 1 copy in chain C.

PF02260
Domain description: FATC domain
Occurring in:
  1. Serine/threonine-protein kinase SMG1
The deposited structure of PDB entry 7pw5 contains 1 copy of Pfam domain PF02260 (FATC domain) in Serine/threonine-protein kinase SMG1. Showing 1 copy in chain A.

PF00454
Domain description: Phosphatidylinositol 3- and 4-kinase
Occurring in:
  1. Serine/threonine-protein kinase SMG1
The deposited structure of PDB entry 7pw5 contains 1 copy of Pfam domain PF00454 (Phosphatidylinositol 3- and 4-kinase) in Serine/threonine-protein kinase SMG1. Showing 1 copy in chain A.

PF15785
Domain description: Serine/threonine-protein kinase smg-1
Occurring in:
  1. Serine/threonine-protein kinase SMG1
The deposited structure of PDB entry 7pw5 contains 1 copy of Pfam domain PF15785 (Serine/threonine-protein kinase smg-1) in Serine/threonine-protein kinase SMG1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000403
Domain description: Phosphatidylinositol 3-/4-kinase, catalytic domain
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR019354
Domain description: Nonsense-mediated mRNA decay factor SMG8-like
Occurring in:
  1. Nonsense-mediated mRNA decay factor SMG8
  2. Nonsense-mediated mRNA decay factor SMG9
IPR003152
Domain description: FATC domain
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Nonsense-mediated mRNA decay factor SMG9
IPR039177
Domain description: Nonsense-mediated mRNA decay factor SMG9
Occurring in:
  1. Nonsense-mediated mRNA decay factor SMG9
IPR028802
Domain description: Nonsense-mediated mRNA decay factor SMG8
Occurring in:
  1. Nonsense-mediated mRNA decay factor SMG8
IPR018936
Domain description: Phosphatidylinositol 3/4-kinase, conserved site
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR036940
Domain description: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR039414
Domain description: SMG1, PIKK catalytic domain
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR014009
Domain description: PIK-related kinase
Occurring in:
  1. Serine/threonine-protein kinase SMG1
IPR031559
Domain description: Serine/threonine-protein kinase SMG1
Occurring in:
  1. Serine/threonine-protein kinase SMG1