› 7pw6

Electron Microscopy
3.05Å resolution

Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body

Released:
DOI: 10.2210/pdb7pw6/pdb
PDB entry 7pw6 coloured by chain, front view.
PDB entry 7pw6 coloured by chain, side view.
PDB entry 7pw6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Langer LM, Bonneau F, Gat Y, Conti E
OpenAccess logo Elife 10 (2021)
PMID: 34698635
Related structures: EMD-13676

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase SMG1 Chain: A
Molecule details ›
Chain: A
Length: 2896 amino acids
Theoretical weight: 320.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96Q15 (Residues: 766-3661; Coverage: 79%)
Gene names: ATX, KIAA0421, LIP, SMG1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand IHP 1 x IHP
Ligand 88C 1 x 88C
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.05Å
Relevant EMDB volumes: EMD-13676
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Translation-coupled mRNA quality control mechanisms.
Monaghan et al. (2023)
2 more

1 mention without citation

Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Langer et al. (2021)