› 7py2

Electron Microscopy
2.59Å resolution

Structure of pathological TDP-43 filaments from ALS with FTLD

Released:
DOI: 10.2210/pdb7py2/pdb
PDB entry 7py2 coloured by chain, front view.
PDB entry 7py2 coloured by chain, side view.
PDB entry 7py2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of pathological TDP-43 filaments from ALS with FTLD.
Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Ryskeldi-Falcon B
Nature 601 139-143 (2022)
PMID: 34880495
Related structures: EMD-13708

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171566 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 414 amino acids
Theoretical weight: 44.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13148 (Residues: 1-414; Coverage: 100%)
Gene names: TARDBP, TDP43
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.59Å
Relevant EMDB volumes: EMD-13708

Quick links

Citations

27 review citations

Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases.
Carey et al. (2022)
26 more

7 mentions without citation

Importin α/β and the tug of war to keep TDP-43 in solution: quo vadis?
Doll et al. (2022)
6 more