› 7pzp

Electron Microscopy
3.5Å resolution

Mitochondrial DNA dependent RNA polymerase homodimer.

Released:
DOI: 10.2210/pdb7pzp/pdb
PDB entry 7pzp coloured by chain, front view.
PDB entry 7pzp coloured by chain, side view.
PDB entry 7pzp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization.
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hällberg BM, Falkenberg M
Cell 185 2309-2323.e24 (2022)
PMID: 35662414
Related structures: EMD-13735

Function and Biology Details

Reaction catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126267 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA-directed RNA polymerase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 1211 amino acids
Theoretical weight: 137.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00411 (Residues: 41-1230; Coverage: 97%)
Gene name: POLRMT
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-13735
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Mechanisms and regulation of human mitochondrial transcription.
Tan et al. (2024)
5 more