› 7q0x

X-ray diffraction
1.09Å resolution

Bovine Trypsin co-crystallized with V(IV)OSO4 and pic

Released:
DOI: 10.2210/pdb7q0x/pdb
Model geometry
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PDB entry 7q0x coloured by chain, front view.
PDB entry 7q0x coloured by chain, side view.
PDB entry 7q0x coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Binding of VIV O2+ , VIV OL, VIV OL2 and VV O2 L Moieties to Proteins: X-ray/Theoretical Characterization and Biological Implications.
Santos MFA, Sciortino G, Correia I, Fernandes ACP, Santos-Silva T, Pisanu F, Garribba E, Costa Pessoa J
Chemistry e202200105 (2022)
PMID: 35486702

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease 1 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin

Ligands and Environments

6 bound ligands:
Ligand V 1 x V
Ligand O 1 x O
Ligand 6PC 2 x 6PC
Ligand GOL 5 x GOL
Ligand SO4 1 x SO4
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P3121
Unit cell:
a: 54.522Å b: 54.522Å c: 108.199Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.113 0.111 0.136
Expression system: Escherichia coli

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Citations

3 citation in other articles

Implications of Protein Interaction in the Speciation of Potential VIVO-Pyridinone Drugs.
Ferraro et al. (2023)
2 more

1 mention without citation

Interaction of Vanadium Complexes with Proteins: Revisiting the Reported Structures in the Protein Data Bank (PDB) since 2015.
Santos et al. (2023)

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