Function and Biology

Human GYS1-GYG1 complex activated state bound to glucose-6-phosphate

Source organism: Homo sapiens
Biochemical function: glycosyltransferase activity
Biological process: glycogen biosynthetic process
Cellular component: membrane

EC 2.4.1.186: Glycogenin glucosyltransferase

Reaction catalysed:
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
Systematic name:
UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase
Alternative Name(s):
  • Glycogenin
  • Priming glucosyltransferase
  • UDP-glucose:glycogenin glucosyltransferase

EC 2.4.1.11: Glycogen(starch) synthase

Reaction catalysed:
UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)
Systematic name:
UDP-alpha-D-glucose:glycogen 4-alpha-D-glucosyltransferase (configuration-retaining)
Alternative Name(s):
  • Glycogen (starch) synthetase
  • UDP-alpha-D-glucose:glycogen 4-alpha-D-glucosyltransferase
  • UDP-glucose--glycogen glucosyltransferase
  • UDP-glycogen synthase
  • UDPG-glycogen synthetase
  • UDPG-glycogen transglucosylase
  • UDPglucose:glycogen 4-alpha-D-glucosyltransferase
  • Uridine diphosphoglucose-glycogen glucosyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01501
Domain description: Glycosyl transferase family 8
Occurring in:
  1. Glycogenin-1
The deposited structure of PDB entry 7q12 contains 8 copies of Pfam domain PF01501 (Glycosyl transferase family 8) in Glycogenin-1. Showing 2 copies in chain B [auth E] (this domain is out of the observed residue ranges!).

PF05693
Domain description: Glycogen synthase
Occurring in:
  1. Glycogen [starch] synthase, muscle
The deposited structure of PDB entry 7q12 contains 4 copies of Pfam domain PF05693 (Glycogen synthase) in Glycogen [starch] synthase, muscle. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Glycogenin-1
IPR008631
Domain description: Glycogen synthase
Occurring in:
  1. Glycogen [starch] synthase, muscle
IPR002495
Domain description: Glycosyl transferase, family 8
Occurring in:
  1. Glycogenin-1