EC 3.4.15.1: Peptidyl-dipeptidase A
Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Systematic name:
-
Alternative Name(s):
- ACE
- Angiotensin I-converting enzyme
- Angiotensin converting enzyme
- Carboxycathepsin
- DCP
- Dipeptidase
- Dipeptide hydrolase
- Dipeptidyl carboxypeptidase
- Dipeptidyl carboxypeptidase I
- Endothelial cell peptidyl dipeptidase
- Kininase II
- PDH
- Peptidase P
- Peptidyl dipeptidase A
- Peptidyl dipeptidase I
- Peptidyl dipeptidase-4
- Peptidyl dipeptide hydrolase
- Peptidyl-dipeptide hydrolase
- Peptidyldipeptide hydrolase
GO terms
Biochemical function:
- metallodipeptidase activity
- mitogen-activated protein kinase binding
- metal ion binding
- bradykinin receptor binding
- mitogen-activated protein kinase kinase binding
- chloride ion binding
- hydrolase activity
- zinc ion binding
- peptidyl-dipeptidase activity
- tripeptidyl-peptidase activity
- exopeptidase activity
- metallopeptidase activity
- peptidase activity
- calmodulin binding
- metalloendopeptidase activity
- metallocarboxypeptidase activity
- carboxypeptidase activity
- endopeptidase activity
Biological process:
- negative regulation of gap junction assembly
- regulation of hematopoietic stem cell proliferation
- blood vessel diameter maintenance
- regulation of heart rate by cardiac conduction
- cell proliferation in bone marrow
- hematopoietic stem cell differentiation
- regulation of angiotensin metabolic process
- heart contraction
- arachidonate secretion
- amyloid-beta metabolic process
- regulation of synaptic plasticity
- peptide catabolic process
- hormone catabolic process
- hormone metabolic process
- angiotensin-activated signaling pathway
- mononuclear cell proliferation
- regulation of vasoconstriction
- regulation of smooth muscle cell migration
- bradykinin catabolic process
- substance P catabolic process
- negative regulation of gene expression
- post-transcriptional regulation of gene expression
- male gonad development
- regulation of blood pressure
- spermatogenesis
- proteolysis
- positive regulation of systemic arterial blood pressure
- regulation of systemic arterial blood pressure by renin-angiotensin
- antigen processing and presentation of peptide antigen via MHC class I
- neutrophil mediated immunity
- regulation of renal output by angiotensin
- angiotensin maturation
- blood vessel remodeling
- kidney development
Protein family (Pfam)
InterPro annotation