› 7q60

Electron Microscopy
3.13Å resolution

Structure of TEV cleaved A2ML1 (A2ML1-TE)

Released:
DOI: 10.2210/pdb7q60/pdb
PDB entry 7q60 coloured by chain, front view.
PDB entry 7q60 coloured by chain, side view.
PDB entry 7q60 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nielsen NS, Zarantonello A, Harwood SL, Jensen KT, Kjøge K, Thøgersen IB, Schauser L, Karlsen JL, Andersen GR, Enghild JJ
OpenAccess logo Nat Commun 13 3033 (2022)
PMID: 35641520
Related structures: EMD-13848

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-2-macroglobulin-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1436 amino acids
Theoretical weight: 159.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A8K2U0 (Residues: 19-1454; Coverage: 100%)
Gene names: A2ML1, CPAMD9
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.13Å
Relevant EMDB volumes: EMD-13848
Expression system: Homo sapiens

Quick links

Citations

3 citation in other articles

Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein.
Harwood et al. (2022)
2 more