7q63

X-ray diffraction
1.9Å resolution

The tandem SH2 domains of SYK

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-155056 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase SYK Chains: AAA, BBB, CCC
Molecule details ›
Chains: AAA, BBB, CCC
Length: 265 amino acids
Theoretical weight: 29.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P43405 (Residues: 6-269; Coverage: 42%)
Gene name: SYK
Sequence domains: SH2 domain

Ligands and Environments

No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2221
Unit cell:
a: 85.902Å b: 152.58Å c: 146.824Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.264
Expression system: Escherichia coli BL21(DE3)