› 7q6k

X-ray diffraction
3.41Å resolution

Crystal structure of the human GDAP1 CMT2 mutant-R120W

Released:
DOI: 10.2210/pdb7q6k/pdb
PDB entry 7q6k coloured by chain, front view.
PDB entry 7q6k coloured by chain, side view.
PDB entry 7q6k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.
Sutinen A, Nguyen GTT, Raasakka A, Muruganandam G, Loris R, Ylikallio E, Tyynismaa H, Bartesaghi L, Ruskamo S, Kursula P
OpenAccess logo FEBS Open Bio 12 1306-1324 (2022)
PMID: 35509130

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186165 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ganglioside-induced differentiation-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 32.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TB36 (Residues: 23-302; Coverage: 78%)
Gene name: GDAP1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P6322
Unit cell:
a: 147.27Å b: 147.27Å c: 114.56Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.252 0.294
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability.
Sutinen et al. (2023)
1 more

1 mention without citation

Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.
Sutinen et al. (2022)