› 7q7e

X-ray diffraction
2.85Å resolution

Room temperature structure of the human Serine/Threonine Kinase 17B (STK17B/DRAK2) in complex with ATP/ADP at atmospheric pressure in a sapphire capillary after high helium gas pressure release

Released:
DOI: 10.2210/pdb7q7e/pdb
PDB entry 7q7e coloured by chain, front view.
PDB entry 7q7e coloured by chain, side view.
PDB entry 7q7e coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lieske J, Guenther S, Saouane S, Meents A

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 17B Chain: A
Molecule details ›
Chain: A
Length: 327 amino acids
Theoretical weight: 37.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94768 (Residues: 25-329; Coverage: 82%)
Gene names: DRAK2, STK17B
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand ATP 1 x ATP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P4122
Unit cell:
a: 84.24Å b: 84.24Å c: 117.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.186 0.239
Expression system: Escherichia coli

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