› 7q8c

Electron Microscopy
2.72Å resolution

Leishmania major actin filament in ADP-state

Released:
DOI: 10.2210/pdb7q8c/pdb
PDB entry 7q8c coloured by chain, front view.
PDB entry 7q8c coloured by chain, side view.
PDB entry 7q8c coloured by chain, top view.
Source organism: Leishmania major
Primary publication:
Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Kotila T, Wioland H, Selvaraj M, Kogan K, Antenucci L, Jégou A, Huiskonen JT, Romet-Lemonne G, Lappalainen P
OpenAccess logo Nat Commun 13 3442 (2022)
PMID: 35705539
Related structures: EMD-13864

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-545674 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 376 amino acids
Theoretical weight: 42.06 KDa
Source organism: Leishmania major
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P45520 (Residues: 1-376; Coverage: 100%)
Sequence domains: Actin

Ligands and Environments

2 bound ligands:
Ligand ADP 5 x ADP
Ligand MG 5 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.72Å
Relevant EMDB volumes: EMD-13864
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Mechanisms of actin disassembly and turnover.
Goode et al. (2023)
2 other articles

1 mention without citation

Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover.
Hvorecny et al. (2024)