› 7qcb

Solution NMR

Williams-Beuren syndrome related methyltransferase WBSCR27 in complex with SAH

Released:
DOI: 10.2210/pdb7qcb/pdb
PDB entry 7qcb coloured by chain, ensemble of 20 models, front view.
PDB entry 7qcb coloured by chain, ensemble of 20 models, side view.
PDB entry 7qcb coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Williams-Beuren Syndrome Related Methyltransferase WBSCR27: From Structure to Possible Function.
Mariasina SS, Chang CF, Navalayeu TL, Chugunova AA, Efimov SV, Zgoda VG, Ivlev VA, Dontsova OA, Sergiev PV, Polshakov VI
OpenAccess logo Front Mol Biosci 9 865743 (2022)
PMID: 35782865

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methyltransferase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 25.99 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8BGM4 (Residues: 3-238; Coverage: 99%)
Gene names: BC002286, Mettl27, Wbscr27
Sequence domains: Methyltransferase domain

Ligands and Environments

1 bound ligand:
Ligand SAH 1 x SAH
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 70%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Williams-Beuren syndrome in pediatric T-cell acute lymphoblastic leukemia: A rare case report and review of literature.
Yang et al. (2024)
1 other article

1 mention without citation

Williams-Beuren Syndrome Related Methyltransferase WBSCR27: From Structure to Possible Function.
Mariasina et al. (2022)