› 7qcu

Electron Microscopy
3.25Å resolution

Structure of the MUCIN-2 Cterminal domains partially deglycosylated.

Released:
DOI: 10.2210/pdb7qcu/pdb
PDB entry 7qcu coloured by chain, front view.
PDB entry 7qcu coloured by chain, side view.
PDB entry 7qcu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Gallego P, Garcia-Bonete MJ, Trillo-Muyo S, Recktenwald CV, Johansson MEV, Hansson GC
OpenAccess logo Nat Commun 14 1969 (2023)
PMID: 37031240
Related structures: EMD-13899

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Mucin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 807 amino acids
Theoretical weight: 88.66 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q02817 (Residues: 4516-5289; Coverage: 15%)
Gene names: MUC2, SMUC
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand CA 2 x CA
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.25Å
Relevant EMDB volumes: EMD-13899
Expression system: Cricetulus griseus

Quick links

Citations

1 review citation

Intestinal mucus and their glycans: A habitat for thriving microbiota.
Luis et al. (2023)
1 other article