› 7qer

Electron Microscopy
2.2Å resolution

human Connexin 26 dodecamer at 55mm Hg PCO2, pH7.4

Released:
DOI: 10.2210/pdb7qer/pdb
PDB entry 7qer coloured by chain, front view.
PDB entry 7qer coloured by chain, side view.
PDB entry 7qer coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational changes and CO2-induced channel gating in connexin26.
Brotherton DH, Savva CG, Ragan TJ, Dale N, Cameron AD
OpenAccess logo Structure 30 697-706.e4 (2022)
PMID: 35276081
Related structures: EMD-13938

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction beta-2 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 230 amino acids
Theoretical weight: 26.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29033 (Residues: 1-226; Coverage: 100%)
Gene name: GJB2
Sequence domains: Connexin

Ligands and Environments

2 bound ligands:
Ligand LMT 48 x LMT
Ligand PTY 12 x PTY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.2Å
Relevant EMDB volumes: EMD-13938
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Diversity in connexin biology.
Lucaciu et al. (2023)
4 other articles

2 mentions without citation

Conformational changes and CO2-induced channel gating in connexin26.
Brotherton et al. (2022)
1 more