› 7qgp

X-ray diffraction
1.9Å resolution

STK10 (LOK) bound to Macrocycle CKJB51

Released:
DOI: 10.2210/pdb7qgp/pdb
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PDB entry 7qgp coloured by chain, front view.
PDB entry 7qgp coloured by chain, side view.
PDB entry 7qgp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Berger B-T, Schroeder M, Kraemer A, Schwalm MP, Kurz CG, Amrhein JA, Hanke T, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand DJ8 1 x DJ8
Ligand EDO 1 x EDO
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 93.312Å b: 61.839Å c: 56.808Å
α: 90° β: 102.79° γ: 90°
R-values:
R R work R free
0.201 0.2 0.237
Expression system: Escherichia coli

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