7qie

X-ray diffraction
2.39Å resolution

Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-186181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 363 amino acids
Theoretical weight: 42.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TBX8 (Residues: 32-421; Coverage: 83%)
Gene names: PIP4K2C, PIP5K2C
Sequence domains: Phosphatidylinositol-4-phosphate 5-Kinase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 49.414Å b: 114.794Å c: 146.853Å
α: 90° β: 95.51° γ: 90°
R-values:
R R work R free
0.214 0.211 0.266
Expression system: Escherichia coli BL21(DE3)