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Cryo-EM structure of human full-length beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25

Source organisms:
Biochemical function: extracellular ligand-gated monoatomic ion channel activity
Biological process: monoatomic ion transmembrane transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02932
Domain description: Neurotransmitter-gated ion-channel transmembrane region
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
The deposited structure of PDB entry 7qnb contains 2 copies of Pfam domain PF02932 (Neurotransmitter-gated ion-channel transmembrane region) in Gamma-aminobutyric acid receptor subunit gamma-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 7qnb contains 3 copies of Pfam domain PF02932 (Neurotransmitter-gated ion-channel transmembrane region) in Gamma-aminobutyric acid receptor subunit beta-3. Showing 1 copy in chain B.

PF02931
Domain description: Neurotransmitter-gated ion-channel ligand binding domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
The deposited structure of PDB entry 7qnb contains 2 copies of Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) in Gamma-aminobutyric acid receptor subunit gamma-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 7qnb contains 3 copies of Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) in Gamma-aminobutyric acid receptor subunit beta-3. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR006201
Domain description: Neurotransmitter-gated ion-channel
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR006028
Domain description: Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR002289
Domain description: Gamma-aminobutyric-acid A receptor, beta subunit
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit beta-3
IPR036734
Domain description: Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR005437
Domain description: Gamma-aminobutyric acid receptor subunit gamma-1/4
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
IPR006029
Domain description: Neurotransmitter-gated ion-channel transmembrane domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR036719
Domain description: Neurotransmitter-gated ion-channel transmembrane domain superfamily
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR038050
Domain description: Neuronal acetylcholine receptor
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR018000
Domain description: Neurotransmitter-gated ion-channel, conserved site
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR006202
Domain description: Neurotransmitter-gated ion-channel ligand-binding domain
Occurring in:
  1. Gamma-aminobutyric acid receptor subunit gamma-2
  2. Gamma-aminobutyric acid receptor subunit beta-3
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Nanobody Nb25
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Nanobody Nb25
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Nanobody Nb25
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nanobody Nb25
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Nanobody Nb25

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