Function and Biology Details
Reaction catalysed:
(1a) ATP + [DNA ligase]-L-lysine = [DNA ligase]-N(6)-(5'-adenylyl)-L-lysine + diphosphate
Sequence domains:
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
PCNA homotrimer and DNA (preferred)
PDBe Complex ID:
PDB-CPX-121857 (preferred)
Entry contents:
3 distinct polypeptide molecules
3 distinct DNA molecules
3 distinct DNA molecules
Macromolecules (6 distinct):
DNA ligase 1
Molecule details ›
Chain: A
Length: 760 amino acids
Theoretical weight: 84.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 760 amino acids
Theoretical weight: 84.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P18858 (Residues: 161-919; Coverage: 83%)
Sequence domains:
Proliferating cell nuclear antigen
Molecule details ›
Chains: B, F, G
Length: 264 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 264 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P12004 (Residues: 1-261; Coverage: 100%)
Sequence domains:
Flap endonuclease 1
Molecule details ›
Chain: Y
Length: 380 amino acids
Theoretical weight: 42.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 380 amino acids
Theoretical weight: 42.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P39748 (Residues: 1-380; Coverage: 100%)
Sequence domains:
