7qql

X-ray diffraction
2.44Å resolution

The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1

Released:
Source organism: Homo sapiens
Primary publication:
A scalable strategy to solve structures of PDZ domains and their complexes.
Acta Crystallogr D Struct Biol 78 509-516 (2022)
PMID: 35362473

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-530107 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Annexin A2; Gamma-2-syntrophin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 408 amino acids
Theoretical weight: 46.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NY99 (Residues: 70-159; Coverage: 17%)
  • Canonical: P07355 (Residues: 29-339; Coverage: 92%)
Gene names: ANX2, ANX2L4, ANXA2, CAL1H, LPC2D, SNTG2
Sequence domains:
Ribosomal protein S6 kinase alpha-1 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 11 amino acids
Theoretical weight: 1.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15418 (Residues: 725-735; Coverage: 2%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 97.46Å b: 60.55Å c: 135.21Å
α: 90° β: 92.42° γ: 90°
R-values:
R R work R free
0.197 0.195 0.23
Expression systems:
  • Escherichia coli
  • Not provided