› 7qun

Electron Microscopy
2.1Å resolution

CryoEM structure of mammalian AAP in complex with Meropenem

Released:
DOI: 10.2210/pdb7qun/pdb
PDB entry 7qun coloured by chain, front view.
PDB entry 7qun coloured by chain, side view.
PDB entry 7qun coloured by chain, top view.
Source organism: Sus scrofa domesticus
Primary publication:
A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex.
Kiss-Szemán AJ, Takács L, Orgován Z, Stráner P, Jákli I, Schlosser G, Masiulis S, Harmat V, Menyhárd DK, Perczel A
OpenAccess logo Chem Sci 13 14264-14276 (2022)
PMID: 36545146
Related structures: EMD-14149

Function and Biology Details

Reaction catalysed: 
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acylamino-acid-releasing enzyme Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 732 amino acids
Theoretical weight: 81.32 KDa
Source organism: Sus scrofa domesticus
UniProt:
  • Canonical: P19205 (Residues: 1-732; Coverage: 100%)
Gene name: APEH
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand DWZ 4 x DWZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.1Å
Relevant EMDB volumes: EMD-14149

Quick links

Citations

1 citations in other articles

Effect of a Declined Plasma Concentration of Valproic Acid Induced by Meropenem on the Antiepileptic Efficacy of Valproic Acid.
Gu et al. (2024)

1 mention without citation

A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex.
Kiss-Szemán et al. (2022)