› 7r0o

X-ray diffraction
2Å resolution

Structure of a cytosolic sulfotransferase of Anopheles gambiae (AGAP001425).

Released:
DOI: 10.2210/pdb7r0o/pdb
PDB entry 7r0o coloured by chain, front view.
PDB entry 7r0o coloured by chain, side view.
PDB entry 7r0o coloured by chain, top view.
Source organism: Anopheles gambiae
Primary publication:
Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues.
Esposito Verza A, Miggiano R, Lombardo F, Fiorillo C, Arcà B, Purghé B, Del Grosso E, Galli U, Rizzi M, Rossi F
OpenAccess logo Curr Res Struct Biol 4 246-255 (2022)
PMID: 35941867

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181874 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 360 amino acids
Theoretical weight: 42.82 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7PXJ0 (Residues: 1-339; Coverage: 100%)
Gene names: 1281751, AgaP_AGAP001425
Sequence domains: Sulfotransferase domain

Ligands and Environments

2 bound ligands:
Ligand GOL 6 x GOL
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 78.773Å b: 92.147Å c: 101.761Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.226
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 mention without citation

Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues.
Esposito Verza et al. (2022)