› 7r2j

X-ray diffraction
1.26Å resolution

Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide

Released:
DOI: 10.2210/pdb7r2j/pdb
PDB entry 7r2j coloured by chain, front view.
PDB entry 7r2j coloured by chain, side view.
PDB entry 7r2j coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Silva DO, Graedler U, Bandeiras TM

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 17.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P30405 (Residues: 44-207; Coverage: 79%)
Gene names: CYP3, PPIF
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Ligands and Environments

2 bound ligands:
Ligand V0Z 1 x V0Z
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P41212
Unit cell:
a: 56.059Å b: 56.059Å c: 85.851Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.141 0.14 0.166
Expression system: Escherichia coli BL21

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