› 7r4a

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175096 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 25.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q460N3 (Residues: 481-678; Coverage: 29%)
Gene names: BAL3, PARP15
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain

Ligands and Environments

2 bound ligands:
Ligand I1B 1 x I1B
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX IV BEAMLINE BioMAX
Spacegroup: P212121
Unit cell:
a: 45.46Å b: 68.74Å c: 159.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.233 0.272
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Privileged Scaffolds for Potent and Specific Inhibitors of Mono-ADP-Ribosylating PARPs.
Nizi et al. (2023)