Assemblies
Multimeric state:
hetero tridecamer
Accessible surface area:
115090.85 Å2
Buried surface area:
45909.25 Å2
Dissociation area:
895.95
Å2
Dissociation energy (ΔGdiss):
-1.51
kcal/mol
Dissociation entropy (TΔSdiss):
21.37
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-121884
Macromolecules
Chain: H
Length: 247 amino acids
Theoretical weight: 28.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Centromere protein H (CENP-H)
InterPro:
Length: 247 amino acids
Theoretical weight: 28.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9H3R5 (Residues: 1-247; Coverage: 100%)
Pfam: Centromere protein H (CENP-H)
InterPro:
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Q9H3R5
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Chain: I
Length: 756 amino acids
Theoretical weight: 86.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Mis6
InterPro: Centromere protein I
Length: 756 amino acids
Theoretical weight: 86.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q92674 (Residues: 1-756; Coverage: 100%)
Pfam: Mis6
InterPro: Centromere protein I
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Q92674
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Chain: K
Length: 269 amino acids
Theoretical weight: 31.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Centromere-associated protein K
InterPro: Centromere protein Cenp-K
Length: 269 amino acids
Theoretical weight: 31.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9BS16 (Residues: 1-269; Coverage: 100%)
Pfam: Centromere-associated protein K
InterPro: Centromere protein Cenp-K
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Q9BS16
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Chain: L
Length: 344 amino acids
Theoretical weight: 39.04 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Kinetochore complex Sim4 subunit Fta1
InterPro: Centromere subunit L
Length: 344 amino acids
Theoretical weight: 39.04 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q8N0S6 (Residues: 1-344; Coverage: 100%)
Pfam: Kinetochore complex Sim4 subunit Fta1
InterPro: Centromere subunit L
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Q8N0S6
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation
Chain: M
Length: 180 amino acids
Theoretical weight: 19.76 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Centromere protein M (CENP-M)
InterPro:
Length: 180 amino acids
Theoretical weight: 19.76 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9NSP4 (Residues: 1-180; Coverage: 100%)
Pfam: Centromere protein M (CENP-M)
InterPro:
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Q9NSP4
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation
Chain: N
Length: 339 amino acids
Theoretical weight: 39.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Kinetochore protein CHL4 like
InterPro: Centromere protein Chl4/mis15/CENP-N
Length: 339 amino acids
Theoretical weight: 39.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q96H22 (Residues: 1-339; Coverage: 100%)
Pfam: Kinetochore protein CHL4 like
InterPro: Centromere protein Chl4/mis15/CENP-N
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Q96H22
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation
Chain: O
Length: 300 amino acids
Theoretical weight: 33.83 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Cenp-O kinetochore centromere component
InterPro: Centromere protein O
Length: 300 amino acids
Theoretical weight: 33.83 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9BU64 (Residues: 1-300; Coverage: 100%)
Pfam: Cenp-O kinetochore centromere component
InterPro: Centromere protein O
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Q9BU64
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation
Chain: P
Length: 288 amino acids
Theoretical weight: 33.21 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P
InterPro: Centromere protein P
Length: 288 amino acids
Theoretical weight: 33.21 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q6IPU0 (Residues: 1-288; Coverage: 100%)
Pfam: CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P
InterPro: Centromere protein P
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Q6IPU0
Chains
Domains
Secondary structure
Interaction interfaces
Sequence conservation
Chain: Q
Length: 268 amino acids
Theoretical weight: 30.65 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: CENP-Q, a CENPA-CAD centromere complex subunit
InterPro: Centromere protein Q
Length: 268 amino acids
Theoretical weight: 30.65 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q7L2Z9 (Residues: 1-268; Coverage: 100%)
Pfam: CENP-Q, a CENPA-CAD centromere complex subunit
InterPro: Centromere protein Q
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Q7L2Z9
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Chain: U
Length: 418 amino acids
Theoretical weight: 47.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: CENP-A nucleosome associated complex (NAC) subunit
InterPro: Centromere protein U
Length: 418 amino acids
Theoretical weight: 47.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q71F23 (Residues: 1-418; Coverage: 100%)
Pfam: CENP-A nucleosome associated complex (NAC) subunit
InterPro: Centromere protein U
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Q71F23
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Chain: R
Length: 177 amino acids
Theoretical weight: 20.23 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Pfam: Kinetochore component, CENP-R
InterPro: Centromere protein R
Length: 177 amino acids
Theoretical weight: 20.23 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q13352 (Residues: 1-177; Coverage: 100%)
Pfam: Kinetochore component, CENP-R
InterPro: Centromere protein R
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Q13352
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Chain C (auth J)
Interaction interfaces
Chain L (auth i)
Interaction interfaces