› 7r8u

X-ray diffraction
1.9Å resolution

LOX-1 - Structural and Functional Studies of a Receptor Implicated in Atherosclerosis

Released:
DOI: 10.2210/pdb7r8u/pdb
Model geometry
Fit model/data
PDB entry 7r8u coloured by chain, front view.
PDB entry 7r8u coloured by chain, side view.
PDB entry 7r8u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies of a monoclonal antibody blocking LOX-1
Ongstad EL, Gaddipati R, Belkhodja M, van Dyk N, Levy S, Sagar D, Cariuk P, Wolny M, Hanna RN, Borrok MJ, Buchanan A, Oganesyan V, Gupta R
Commun Med (2023)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211522 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Oxidized low-density lipoprotein receptor 1, soluble form Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 132 amino acids
Theoretical weight: 15.03 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P78380 (Residues: 140-271; Coverage: 48%)
Gene names: CLEC8A, LOX1, OLR1
Sequence domains: Lectin C-type domain
Antigen binding fragment, Vh and Ch1 Chain: HHH
Molecule details ›
Chain: HHH
Length: 230 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Antibody light chain, kappa Chain: LLL

Ligands and Environments

1 bound ligand:
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P212121
Unit cell:
a: 71.908Å b: 89.901Å c: 110.925Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.218
Expression system: Cricetulus griseus

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