› 7rau

Electron Microscopy
3.99Å resolution

Structure of TRPV3 in complex with osthole

Released:
DOI: 10.2210/pdb7rau/pdb
PDB entry 7rau coloured by chain, front view.
PDB entry 7rau coloured by chain, side view.
PDB entry 7rau coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
Neuberger A, Nadezhdin KD, Zakharian E, Sobolevsky AI
EMBO Rep 22 e53233 (2021)
PMID: 34472684
Related structures: EMD-24386

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 808 amino acids
Theoretical weight: 92.48 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8K424 (Residues: 1-791; Coverage: 100%)
Gene name: Trpv3
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand A0O 8 x A0O
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.99Å
Relevant EMDB volumes: EMD-24386
Expression system: Homo sapiens

Quick links

Citations

7 review citations

TRP channels: a journey towards a molecular understanding of pain.
Rosenbaum et al. (2022)
6 more

2 mentions without citation

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
1 more