› 7rbq

X-ray diffraction
2.2Å resolution

Co-crystal structure of human PRMT9 in complex with MT556 inhibitor

Released:
DOI: 10.2210/pdb7rbq/pdb
Model geometry
Fit model/data
PDB entry 7rbq coloured by chain, front view.
PDB entry 7rbq coloured by chain, side view.
PDB entry 7rbq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zeng H, Dong A, Hutchinson A, Seitova A, Li Y, Gao YD, Schneider S, Siliphaivanh P, Sloman D, Nicholson B, Fischer C, Hicks J, Brown PJ, Arrowsmith CH, Edwards AM, Halabelian L, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein arginine N-methyltransferase 9 Chain: A
Molecule details ›
Chain: A
Length: 719 amino acids
Theoretical weight: 80.43 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6P2P2 (Residues: 127-845; Coverage: 85%)
Gene names: PRMT10, PRMT9
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 44T 1 x 44T
Ligand EDO 1 x EDO
Ligand UNX 5 x UNX
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 64.044Å b: 82.061Å c: 65.767Å
α: 90° β: 97.71° γ: 90°
R-values:
R R work R free
0.215 0.212 0.271
Expression system: Spodoptera frugiperda

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