7rcb

X-ray diffraction
2Å resolution

Crystal Structure of a PMS2 VUS

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-156980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mismatch repair endonuclease PMS2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 365 amino acids
Theoretical weight: 40.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54278 (Residues: 1-365; Coverage: 42%)
Gene names: PMS2, PMSL2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BRUKER IMUS MICROFOCUS
Spacegroup: P212121
Unit cell:
a: 75.219Å b: 75.262Å c: 134.872Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.162 0.198
Expression system: Escherichia coli BL21(DE3)