› 7rd3

X-ray diffraction
1.81Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-527081 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
antibody m42.126 heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 255 amino acids
Theoretical weight: 27.54 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
antibody m42.126 light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 220 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Circumsporozoite protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.56 KDa
Source organism: Plasmodium falciparum
Expression system: Not provided
UniProt:
  • Canonical: P02893 (Residues: 120-134; Coverage: 4%)
Gene name: CSP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 54.854Å b: 57.176Å c: 74.493Å
α: 86.5° β: 76.86° γ: 72.44°
R-values:
R R work R free
0.218 0.216 0.26
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

Progress in building clinically relevant patient-derived tumor xenograft models for cancer research.
Wang et al. (2023)
1 more

1 mention without citation

Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.
Kratochvil et al. (2021)