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Crystal Structure of a Stable Heparanase Mutant

Source organism: Homo sapiens
Biochemical function: hydrolase activity, acting on glycosyl bonds
Biological process: not assigned
Cellular component: membrane

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EC 3.2.1.166: Heparanase

Reaction catalysed:
Endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan
Systematic name:
Heparan sulfate N-sulfo-D-glucosamine endoglucanase
Alternative Name(s):
  • C1A heparanase
  • HPSE
  • Heparanase 1
  • Heparanase-1
  • Hpa1
  • Hpa1 heparanase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF03662
Domain description: Glycosyl hydrolase family 79, N-terminal domain
Occurring in:
  1. Heparanase 50 kDa subunit
The deposited structure of PDB entry 7rg8 contains 1 copy of Pfam domain PF03662 (Glycosyl hydrolase family 79, N-terminal domain ) in Heparanase 50 kDa subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Heparanase 50 kDa subunit
IPR005199
Domain description: Glycoside hydrolase, family 79
Occurring in:
  1. Heparanase 50 kDa subunit

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