7rgp

Electron Microscopy
2.9Å resolution

cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-209392 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Guanine nucleotide-binding protein G(i) subunit alpha-3; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 43.39 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 350 amino acids
Theoretical weight: 38.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Single-chain variable fragment 16 Chain: E
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
nanobody 35 Chain: N
Tirzepatide Chain: P
Glucagon-like peptide 1 receptor Chain: R

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-24453
Expression systems:
  • Trichoplusia ni
  • Spodoptera frugiperda
  • Escherichia coli
  • Not provided