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Mycobacterial CIII2CIV2 supercomplex, inhibitor free, -Lpqe cyt cc open

Source organism: Mycolicibacterium smegmatis MC2 155
Biochemical function: oxidoreductase activity
Biological process: proton transmembrane transport
Cellular component: membrane

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EC 7.1.1.9: Cytochrome-c oxidase

Reaction catalysed:
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Systematic name:
Ferrocytochrome-c:oxygen oxidoreductase
Alternative Name(s):
  • Complex IV (mitochondrial electron transport)
  • Cytochrome a3
  • Cytochrome aa3
  • Cytochrome ba(3)
  • Cytochrome bb3
  • Cytochrome caa(3)
  • Cytochrome cbb(3)
  • Cytochrome oxidase
  • Ferrocytochrome c oxidase
  • Indophenol oxidase
  • Indophenolase
  • NADH cytochrome c oxidase
  • Warburg's respiratory enzyme

EC 7.1.1.8: Quinol--cytochrome-c reductase

Reaction catalysed:
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
Systematic name:
Quinol:ferricytochrome-c oxidoreductase
Alternative Name(s):
  • CoQH(2)--cytochrome c oxidoreductase
  • Coenzyme Q--cytochrome c reductase
  • Coenzyme QH(2)--cytochrome c reductase
  • Complex III (mitochondrial electron transport)
  • Cytochrome bc1 complex
  • Dihydrocoenzyme Q--cytochrome c reductase
  • Mitochondrial electron transport complex III
  • QH(2):cytochrome c oxidoreductase
  • Reduced coenzyme Q-cytochrome c reductase
  • Reduced ubiquinone--cytochrome c oxidoreductase
  • Reduced ubiquinone--cytochrome c reductase, complex III (mitochondrial electron transport)
  • Ubihydroquinol:cytochrome c oxidoreductase
  • Ubiquinol--cytochrome c oxidoreductase
  • Ubiquinol--cytochrome c-2 oxidoreductase
  • Ubiquinol--cytochrome c1 oxidoreductase
  • Ubiquinol--cytochrome c2 reductase
  • Ubiquinol--cytochrome-c reductase
  • Ubiquinol:ferricytochrome-c oxidoreductase
  • Ubiquinone--cytochrome b-c(1) oxidoreductase
  • Ubiquinone--cytochrome c oxidoreductase
  • Ubiquinone--cytochrome-c oxidoreductase
  • Ubiquinone-cytochrome c reductase

EC 1.15.1.1: Superoxide dismutase

Reaction catalysed:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Systematic name:
Superoxide:superoxide oxidoreductase
Alternative Name(s):
  • Copper-zinc superoxide dismutase
  • Cu,Zn-SOD
  • Cu-Zn superoxide dismutase
  • Cuprein
  • Cytocuprein
  • Erythrocuprein
  • Fe-SOD
  • Ferrisuperoxide dismutase
  • Hemocuprein
  • Hepatocuprein
  • Mn-SOD
  • SOD
  • SOD-1
  • SOD-2
  • SOD-3
  • SOD-4
  • SODF
  • SODS
  • Superoxidase dismutase
  • Superoxide dismutase I
  • Superoxide dismutase II

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF17174
Domain description: Domain of unknown function (DUF5130)
Occurring in:
  1. Uncharacterized protein MSMEG_4692/MSMEI_4575
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF17174 (Domain of unknown function (DUF5130)) in Uncharacterized protein MSMEG_4692/MSMEI_4575. Showing 1 copy in chain N [auth V].

PF12270
Domain description: Cytochrome c oxidase subunit IV
Occurring in:
  1. Cytochrome c oxidase polypeptide 4
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF12270 (Cytochrome c oxidase subunit IV) in Cytochrome c oxidase polypeptide 4. Showing 1 copy in chain L [auth T].

PF00510
Domain description: Cytochrome c oxidase subunit III
Occurring in:
  1. Probable cytochrome c oxidase subunit 3
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF00510 (Cytochrome c oxidase subunit III) in Probable cytochrome c oxidase subunit 3. Showing 1 copy in chain D [auth S].

PF00355
Domain description: Rieske [2Fe-2S] domain
Occurring in:
  1. Cytochrome bc1 complex Rieske iron-sulfur subunit
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF00355 (Rieske [2Fe-2S] domain) in Cytochrome bc1 complex Rieske iron-sulfur subunit. Showing 1 copy in chain C [auth M].

PF19297
Domain description: QcrA subunit N-terminal region
Occurring in:
  1. Cytochrome bc1 complex Rieske iron-sulfur subunit
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF19297 (QcrA subunit N-terminal region) in Cytochrome bc1 complex Rieske iron-sulfur subunit. Showing 1 copy in chain C [auth M].

PF00116
Domain description: Cytochrome C oxidase subunit II, periplasmic domain
Occurring in:
  1. cytochrome-c oxidase
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF00116 (Cytochrome C oxidase subunit II, periplasmic domain) in cytochrome-c oxidase. Showing 1 copy in chain P [auth K].

PF10939
Domain description: Protein of unknown function (DUF2631)
Occurring in:
  1. Transmembrane protein
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF10939 (Protein of unknown function (DUF2631) ) in Transmembrane protein. Showing 1 copy in chain H [auth J].

PF13442
Domain description: Cytochrome C oxidase, cbb3-type, subunit III
Occurring in:
  1. Cytochrome bc1 complex cytochrome c subunit
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF13442 (Cytochrome C oxidase, cbb3-type, subunit III ) in Cytochrome bc1 complex cytochrome c subunit. Showing 1 copy in chain V [auth I].

PF00034
Domain description: Cytochrome c
Occurring in:
  1. Cytochrome bc1 complex cytochrome c subunit
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF00034 (Cytochrome c) in Cytochrome bc1 complex cytochrome c subunit. Showing 1 copy in chain V [auth I].

PF13631
Domain description: Cytochrome b(N-terminal)/b6/petB
Occurring in:
  1. Cytochrome bc1 complex cytochrome b subunit
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF13631 (Cytochrome b(N-terminal)/b6/petB) in Cytochrome bc1 complex cytochrome b subunit. Showing 1 copy in chain E.

PF00080
Domain description: Copper/zinc superoxide dismutase (SODC)
Occurring in:
  1. Superoxide dismutase [Cu-Zn]
The deposited structure of PDB entry 7rh6 contains 2 copies of Pfam domain PF00080 (Copper/zinc superoxide dismutase (SODC)) in Superoxide dismutase [Cu-Zn]. Showing 1 copy in chain I [auth D].

InterPro InterPro annotations
IPR000883
Domain description: Cytochrome c oxidase subunit I
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR009056
Domain description: Cytochrome c-like domain
Occurring in:
  1. Cytochrome bc1 complex cytochrome c subunit
IPR036909
Domain description: Cytochrome c-like domain superfamily
Occurring in:
  1. Cytochrome bc1 complex cytochrome c subunit
IPR021050
Domain description: Cytochrome c oxidase subunit IV, actinobacteria
Occurring in:
  1. Cytochrome c oxidase polypeptide 4
IPR000298
Domain description: Cytochrome c oxidase subunit III-like
Occurring in:
  1. Probable cytochrome c oxidase subunit 3
IPR017941
Domain description: Rieske [2Fe-2S] iron-sulphur domain
Occurring in:
  1. Cytochrome bc1 complex Rieske iron-sulfur subunit
IPR036922
Domain description: Rieske [2Fe-2S] iron-sulphur domain superfamily
Occurring in:
  1. Cytochrome bc1 complex Rieske iron-sulfur subunit
IPR036927
Domain description: Cytochrome c oxidase-like, subunit I superfamily
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR002429
Domain description: Cytochrome c oxidase subunit II-like C-terminal
Occurring in:
  1. cytochrome-c oxidase
IPR008972
Domain description: Cupredoxin
Occurring in:
  1. cytochrome-c oxidase
IPR036257
Domain description: Cytochrome C oxidase subunit II, transmembrane domain superfamily
Occurring in:
  1. cytochrome-c oxidase
IPR005797
Domain description: Cytochrome b/b6, N-terminal domain
Occurring in:
  1. Cytochrome bc1 complex cytochrome b subunit
IPR036423
Domain description: Superoxide dismutase-like, copper/zinc binding domain superfamily
Occurring in:
  1. Superoxide dismutase [Cu-Zn]
IPR033437
Domain description: Protein of unknown function DUF5130
Occurring in:
  1. Uncharacterized protein MSMEG_4692/MSMEI_4575
IPR013833
Domain description: Cytochrome c oxidase, subunit III, 4-helical bundle
Occurring in:
  1. Probable cytochrome c oxidase subunit 3
IPR024791
Domain description: Cytochrome c oxidase subunit III
Occurring in:
  1. Probable cytochrome c oxidase subunit 3
IPR035973
Domain description: Cytochrome c oxidase subunit III-like superfamily
Occurring in:
  1. Probable cytochrome c oxidase subunit 3
IPR014349
Domain description: Rieske iron-sulphur protein
Occurring in:
  1. Cytochrome bc1 complex Rieske iron-sulfur subunit
IPR045603
Domain description: QcrA subunit, N-terminal
Occurring in:
  1. Cytochrome bc1 complex Rieske iron-sulfur subunit
IPR023615
Domain description: Cytochrome c oxidase, subunit I, copper-binding site
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR014241
Domain description: Cytochrome c oxidase, subunit I bacterial type
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR023616
Domain description: Cytochrome c oxidase-like, subunit I domain
Occurring in:
  1. Cytochrome c oxidase subunit 1
IPR001505
Domain description: Copper centre Cu(A)
Occurring in:
  1. cytochrome-c oxidase
IPR045187
Domain description: Cytochrome c/quinol oxidase subunit II
Occurring in:
  1. cytochrome-c oxidase
IPR024341
Domain description: Protein of unknown function DUF2631
Occurring in:
  1. Transmembrane protein
IPR016174
Domain description: Di-haem cytochrome, transmembrane
Occurring in:
  1. Cytochrome bc1 complex cytochrome b subunit
IPR027387
Domain description: Cytochrome b/b6-like domain superfamily
Occurring in:
  1. Cytochrome bc1 complex cytochrome b subunit
IPR018152
Domain description: Superoxide dismutase, copper/zinc, binding site
Occurring in:
  1. Superoxide dismutase [Cu-Zn]
IPR001424
Domain description: Superoxide dismutase, copper/zinc binding domain
Occurring in:
  1. Superoxide dismutase [Cu-Zn]

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