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Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state

Source organism: Homo sapiens
Biochemical function: intracellularly cyclic nucleotide-activated monoatomic cation channel activity
Biological process: transmembrane transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00027
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
  2. Cyclic nucleotide-gated channel beta-1
The deposited structure of PDB entry 7rhk contains 3 copies of Pfam domain PF00027 (Cyclic nucleotide-binding domain) in Cyclic nucleotide-gated channel alpha-1. Showing 1 copy in chain C [auth A].
The deposited structure of PDB entry 7rhk contains 1 copy of Pfam domain PF00027 (Cyclic nucleotide-binding domain) in Cyclic nucleotide-gated channel beta-1. Showing 1 copy in chain B.

PF16526
Domain description: C-terminal leucine zipper domain of cyclic nucleotide-gated channels
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
The deposited structure of PDB entry 7rhk contains 3 copies of Pfam domain PF16526 (C-terminal leucine zipper domain of cyclic nucleotide-gated channels ) in Cyclic nucleotide-gated channel alpha-1. Showing 1 copy in chain C [auth A].

PF00520
Domain description: Ion transport protein
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
The deposited structure of PDB entry 7rhk contains 3 copies of Pfam domain PF00520 (Ion transport protein) in Cyclic nucleotide-gated channel alpha-1. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR000595
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
  2. Cyclic nucleotide-gated channel beta-1
IPR018488
Domain description: Cyclic nucleotide-binding, conserved site
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
  2. Cyclic nucleotide-gated channel beta-1
IPR014710
Domain description: RmlC-like jelly roll fold
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
  2. Cyclic nucleotide-gated channel beta-1
IPR018490
Domain description: Cyclic nucleotide-binding domain superfamily
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
  2. Cyclic nucleotide-gated channel beta-1
IPR032406
Domain description: Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1
IPR005821
Domain description: Ion transport domain
Occurring in:
  1. Cyclic nucleotide-gated channel alpha-1

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