› 7rhn

X-ray diffraction
2.46Å resolution

Co-crystal structure of Q67H mutant of disulfide stabilized HIV-1 CA hexamer and lenacapavir

Released:
DOI: 10.2210/pdb7rhn/pdb
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PDB entry 7rhn coloured by chain, front view.
PDB entry 7rhn coloured by chain, side view.
PDB entry 7rhn coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.
Bester SM, Adu-Ampratwum D, Annamalai AS, Wei G, Briganti L, Murphy BC, Haney R, Fuchs JR, Kvaratskhelia M
OpenAccess logo mBio e0180422 (2022)
PMID: 36190128

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: C
Molecule details ›
Chain: C
Length: 231 amino acids
Theoretical weight: 25.47 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand QNG 1 x QNG
Ligand IOD 3 x IOD
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P6
Unit cell:
a: 89.73Å b: 89.73Å c: 56.092Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.242 0.288
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

HIV-1 capsid and viral DNA integration.
Dwivedi et al. (2024)
3 more

2 mentions without citation

Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.
Bester et al. (2022)
1 more

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