› 7rki

X-ray diffraction
2.09Å resolution

Griffithsin-S10Y/S42Y/S88Y

Released:
DOI: 10.2210/pdb7rki/pdb
PDB entry 7rki coloured by chain, front view.
PDB entry 7rki coloured by chain, side view.
PDB entry 7rki coloured by chain, top view.
Source organism: Griffithsia sp. Q66D336
Primary publication:
C3-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity.
Sun J, Zhao G, Bylund T, Lee M, Adibhatla S, Kwong PD, Chuang GY, Rawi R, Bewley CA
ACS Chem Biol 17 1450-1459 (2022)
PMID: 35537058

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160913 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Griffithsin Chains: A, B
Molecule details ›
Chains: A, B
Length: 142 amino acids
Theoretical weight: 15.05 KDa
Source organism: Griffithsia sp. Q66D336
Expression system: Escherichia coli
UniProt:
  • Canonical: P84801 (Residues: 2-121; Coverage: 99%)
Sequence domains: Jacalin-like lectin domain

Ligands and Environments

1 bound ligand:
Ligand MAN 3 x MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU R-AXIS IV
Spacegroup: P212121
Unit cell:
a: 57.745Å b: 59.655Å c: 67.288Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.173 0.229
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

C3-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity.
Sun et al. (2022)