› 7rlt

Electron Microscopy
3.7Å resolution

Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase)

Released:
DOI: 10.2210/pdb7rlt/pdb
PDB entry 7rlt coloured by chain, front view.
PDB entry 7rlt coloured by chain, side view.
PDB entry 7rlt coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of putative tumor suppressor ALDH1L1.
Tsybovsky Y, Sereda V, Golczak M, Krupenko NI, Krupenko SA
OpenAccess logo Commun Biol 5 3 (2022)
PMID: 35013550
Related structures: EMD-24540

Function and Biology Details

Reaction catalysed: 
10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic 10-formyltetrahydrofolate dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 902 amino acids
Theoretical weight: 98.99 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P28037 (Residues: 1-902; Coverage: 100%)
Gene names: Aldh1l1, Fthfd
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PNS 4 x PNS
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.7Å
Relevant EMDB volumes: EMD-24540
Expression system: Trichoplusia ni

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Citations

1 mention without citation

Structure of putative tumor suppressor ALDH1L1.
Tsybovsky et al. (2022)