› 7rqx

Electron Microscopy
3.36Å resolution

Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A

Released:
DOI: 10.2210/pdb7rqx/pdb
PDB entry 7rqx coloured by chain, front view.
PDB entry 7rqx coloured by chain, side view.
PDB entry 7rqx coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Kwon DH, Zhang F, Fedor JG, Suo Y, Lee SY
OpenAccess logo Nat Commun 13 2874 (2022)
PMID: 35610228
Related structures: EMD-24639

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 868 amino acids
Theoretical weight: 98.72 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35433 (Residues: 1-838; Coverage: 100%)
Gene names: Trpv1, Vr1, Vr1l
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand LBN 8 x LBN
Ligand 6OU 12 x 6OU
Ligand 6EU 4 x 6EU
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-24639
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Carcinogenesis and Metastasis: Focus on TRPV1-Positive Neurons and Immune Cells.
Erin et al. (2023)
1 more

3 mentions without citation

Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1.
Chu et al. (2023)
2 more