› 7rrb

X-ray diffraction
2.69Å resolution

Function and Biology Details

Reaction catalysed: 
D-tryptophan + O(2) = N-formyl-D-kynurenine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147133 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Indoleamine 2,3-dioxygenase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 44.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14902 (Residues: 11-403; Coverage: 98%)
Gene names: IDO, IDO1, INDO
Sequence domains: Indoleamine 2,3-dioxygenase

Ligands and Environments

1 bound ligand:
Ligand 6ZI 2 x 6ZI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 86.099Å b: 94.724Å c: 129.154Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.245
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Oxetanes in Drug Discovery Campaigns.
Rojas et al. (2023)
1 other article

2 mentions without citation

Overcoming universal restrictions on metal selectivity by protein design.
Choi et al. (2022)
1 more