› 7rtm

Electron Microscopy
3.4Å resolution

Cryo-EM Structure of the Sodium-driven Chloride/Bicarbonate Exchanger NDCBE (SLC4A8)

Released:
DOI: 10.2210/pdb7rtm/pdb
PDB entry 7rtm coloured by chain, front view.
PDB entry 7rtm coloured by chain, side view.
PDB entry 7rtm coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE.
Wang W, Tsirulnikov K, Zhekova HR, Kayık G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Zhou ZH, Pushkin A, Kurtz I
OpenAccess logo Nat Commun 12 5690 (2021)
PMID: 34584093
Related structures: EMD-24683

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Electroneutral sodium bicarbonate exchanger 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 571 amino acids
Theoretical weight: 64.3 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6RVG2 (Residues: 451-1021; Coverage: 52%)
Gene names: Ndcbe1, Slc4a8
Sequence domains: HCO3- transporter integral membrane domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 2 x NAG
Ligand NA 2 x NA
Ligand CO3 2 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-24683
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Intracellular pH Control by Membrane Transport in Mammalian Cells. Insights Into the Selective Advantages of Functional Redundancy.
Doyen et al. (2022)
4 more

4 mentions without citation

Substrate binding and inhibition of the anion exchanger 1 transporter.
Capper et al. (2023)
3 more