› 7rtt

Electron Microscopy
3.5Å resolution

Cryo-EM structure of a TTYH2 cis-dimer

Released:
DOI: 10.2210/pdb7rtt/pdb
PDB entry 7rtt coloured by chain, front view.
PDB entry 7rtt coloured by chain, side view.
PDB entry 7rtt coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization.
Li B, Hoel CM, Brohawn SG
Nat Commun 12 6913 (2021)
PMID: 34824283
Related structures: EMD-24688

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174816 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protein tweety homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 540 amino acids
Theoretical weight: 59.94 KDa
Source organism: Mus musculus
Expression system: Mammalia
UniProt:
  • Canonical: Q3TH73 (Residues: 2-532; Coverage: 100%)
Gene name: Ttyh2
Sequence domains: Tweety

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Ligand NAG 8 x NAG
Ligand BMA 4 x BMA
1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-24688
Expression system: Mammalia

Quick links

Citations

2 review citations

Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC. Part 1: from its discovery and phenotype characterization to the molecular entity identification.
Okada Y. (2024)
1 more

1 mention without citation

Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization.
Li et al. (2021)